Here is the Material Safety Data Sheet (MSDS) for Praziquantel:
Product Name: Praziquantel
Synonyms: 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one
CAS Number: 55268-74-1
Section 1: Identification
Product Identifier: Praziquantel
Recommended Use: Pharmaceutical
Manufacturer/Supplier: Multiple manufacturers/suppliers
Emergency Phone Number: For emergencies, contact your local Poison Control Center or call 911.
Section 2: Hazard(s) Identification
Physical and chemical hazards: Praziquantel is stable under normal conditions. It may release toxic fumes or gases when exposed to high temperatures or flames.
Health hazards: Praziquantel may cause skin irritation, eye irritation, and respiratory tract irritation. Ingestion of high doses may cause nausea, vomiting, abdominal pain, and diarrhea. Long-term exposure may cause liver damage.
Environmental hazards: Praziquantel is toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment.
Section 3: Composition / Information on Ingredients
Chemical name: Praziquantel
CAS number: 55268-74-1
Molecular formula: C19H24N2O2
Molecular weight: 312.41 g/mol
%: >99
Section 4: First Aid Measures
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Skin Contact: Remove contaminated clothing and shoes. Wash skin with soap and water for at least 15 minutes. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Section 5: Fire Fighting Measures
Flammability: Praziquantel is not flammable.
Fire-fighting instructions: Use water spray, foam, dry chemical, or carbon dioxide to extinguish fires involving praziquantel. Wear appropriate protective equipment.
Section 6: Accidental Release Measures
Personal precautions: Wear appropriate personal protective equipment.
Environmental precautions: Do not allow praziquantel to enter the environment. Contain the spill and prevent it from spreading.
Cleanup methods: Clean up the spill using absorbent materials. Dispose of waste according to local regulations.
Section 7: Handling and Storage
Handling: Use appropriate personal protective equipment. Avoid contact with eyes, skin, and clothing.
Storage: Store in a cool, dry, well-ventilated area away from incompatible materials.
Section 8: Exposure Controls / Personal Protection
Engineering Controls: Use adequate ventilation.
Personal Protective Equipment: Use appropriate protective gloves, clothing, and eye/face protection.
Section 9: Physical and Chemical Properties
Appearance: White or off-white powder
Odor: Odorless
Melting Point: 136-140°C
Solubility: Soluble in water, methanol, and dimethyl sulfoxide
pH: Not applicable
Section 10: Stability and Reactivity
Stability: Praziquantel is stable under normal conditions of use and storage.
Reactivity: Praziquantel may react with strong oxidizing agents and acids.
Hazardous decomposition products: May release toxic fumes and gases when exposed to high temperatures or flames.
Section 11: Toxicological Information
Acute Toxicity: LD50 (rat, oral) >2,000 mg/kg
Chronic Toxicity: Not determined
Section 12: Ecological Information
Environmental Toxicity: Not determined
Section 13: Disposal Considerations
Disposal: Dispose of in accordance with local, state, and federal regulations.
Section 14: Transportation Information
Shipping Information: Not regulated as a hazardous material.
Section 15: Regulatory Information
Regulatory Information: This product is not subject to any regulations under the Federal Occupational Safety and Health Act, the Clean Air Act, the Clean Water Act, or the Resource Conservation and Recovery Act.
Section 16: Other Information
Other Information: This Material Safety Data Sheet (MSDS) is provided as a courtesy to assist in the safe handling and proper use of this product.
Jiayi Pharmaceutical - the global leader in praziquantel technology!
1. Specialized in praziquantel for 20 years, strategic cooperation with domestic and foreign famous enterprises!
Shanghai Jiayi is the earliest professional manufacturer of praziquantel GMP factory in China, which passed the GMP certification of veterinary medicine of the Ministry of Agriculture in 2011, obtained the registration in Japan in 2012, obtained the COS certificate of EU in 2016, registered in India in 2014, and registered and certified in many countries, and the products are exported to more than 60 countries and regions.
2. High-cost performance, high-end API casting world brand formulation enterprises, to achieve win-win!
Based on technological progress and adopting international standards, the company is committed to building a globally competitive and influential production base of high-end characteristic APIs for insect repellents and becoming a one-stop expert in insect repellent APIs to serve users all over the world.
3. The scale of praziquantel API is in the first place, the supply is guaranteed, and the cooperation is more permanent!
With the pursuit of quality and customers' trust over the years, our products are exported to more than 60 countries and regions in Europe, America, Asia, Australia and Africa. Jiayi has established a long-term and stable strategic partnership with world-renowned enterprises such as Bayer, Sanofi, Boehringer Ingelheim, etc., and cooperated closely with domestic famous enterprises, "Jiayi" praziquantel API is a big national brand, which enjoys a high reputation at home and abroad and has the top market share.